Russia's Covid19 Vaccine According to The Lancet

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Sertorio
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Russia's Covid19 Vaccine According to The Lancet

Post by Sertorio » Fri Sep 04, 2020 5:04 am

Results of Russia's COVID-19 vaccine produced antibody response: The Lancet
https://www.reuters.com/article/us-heal ... SKBN25V1I2

MOSCOW (Reuters) - Russia’s “Sputnik-V” COVID-19 vaccine produced an antibody response in all participants in early-stage trials, according to results published on Friday by The Lancet medical journal that were hailed by Moscow as an answer to its critics.

The results of the two trials, conducted in June-July this year and involving 76 participants, showed 100% of participants developing antibodies to the new coronavirus and no serious side effects, The Lancet said.

Russia licensed the two-shot jab for domestic use in August, the first country to do so and before any data had been published or a large-scale trial begun.

“The two 42-day trials – including 38 healthy adults each – did not find any serious adverse effects among participants, and confirmed that the vaccine candidates elicit an antibody response,” The Lancet said.

“Large, long-term trials including a placebo comparison, and further monitoring are needed to establish the long-term safety and effectiveness of the vaccine for preventing COVID-19 infection,” it said.

The vaccine is named Sputnik-V in homage to the world’s first satellite, launched by the Soviet Union. Some Western experts have warned against its use until all internationally approved testing and regulatory steps have been taken.

But with the results now published for the first time in an international peer-reviewed journal, and with a 40,000-strong later-stage trial launched last week, a senior Russian official said Moscow had faced down its critics abroad.

“With this (publication) we answer all of the questions of the West that were diligently asked over the past three weeks, frankly with the clear goal of tarnishing the Russian vaccine,” said Kirill Dmitriev, the head of the Russian Direct Investment Fund (RDIF), Russia’s sovereign wealth fund, which has backed the vaccine.

“All of the boxes are checked,” he told Reuters. “Now... we will start asking questions of some of the Western vaccines.”

Dmitriev said at least 3,000 people had already been recruited for the large-scale trial of the Sputnik-V vaccine launched last week, and initial results were expected in October or November this year.

Commenting on the results of the early-stage trials, lead author Dr Naor Bar-Zeev of the International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, USA said the studies were “encouraging but small”.

Bar-Zeev, who was not involved in the study, said “clinical efficacy for any COVID-19 vaccine has not yet been shown.”

RACE TO DEVELOP VACCINE

Governments and big pharmaceutical firms are racing to develop a vaccine to end the COVID-19 pandemic, which has killed more than 850,000 people globally and infected around 26 million.

More than half a dozen drugmakers are already conducting advanced clinical trials, each with tens of thousands of participants and several, including Britain’s AstraZeneca and U.S. drugmakers Moderna and Pfizer expect to know if their COVID-19 vaccines work and are safe by the end of this year.

The Lancet said the early-stage trials suggested the Sputnik-V vaccine produced a response in a component of the immune system known as T cells.

Scientists have been scrutinising the role played by T cells in battling coronavirus infection, with recent findings showing these cells may provide longer-term protection than antibodies.

The vaccine, developed by Moscow’s Gamaleya Institute, is administered in two doses, with each based on a different vector that normally causes the common cold: human adenoviruses Ad5 and Ad26.

Some experts have said that using this delivery mechanism could make a COVID-19 vaccine less effective, since many people have already been exposed to the Ad5 adenovirus and developed immunity to it.

In China and the United States, about 40% of people have high levels of antibodies from prior Ad5 exposure. In Africa, it could be has high as 80%, experts have said.

Denis Logunov, one of the vaccine’s developers at the Gamaleya Institute, told Reuters the vaccine uses a strong enough dose of Ad5 to overcome any earlier immunity, without compromising safety.

The booster dose, based on the rarer Ad26 adenovirus, provides further support because the likelihood of widespread immunity to both types in the population is minimal, he said.

Russia has said it expects to produce between 1.5 million and 2 million doses per month of its potential COVID-19 vaccine by the end of the year, gradually increasing production to 6 million doses a month.
But western countries prefer to ignore positive assessments like this, and are getting ready to impose on their people less efficient - and probably more expensive - vaccines. The least one should expect from governments is an open mind, but that's impossible when Russia is involved.

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Doc
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Re: Russia's Covid19 Vaccine According to The Lancet

Post by Doc » Fri Sep 04, 2020 7:23 am

Sertorio wrote:
Fri Sep 04, 2020 5:04 am
Results of Russia's COVID-19 vaccine produced antibody response: The Lancet
https://www.reuters.com/article/us-heal ... SKBN25V1I2

MOSCOW (Reuters) - Russia’s “Sputnik-V” COVID-19 vaccine produced an antibody response in all participants in early-stage trials, according to results published on Friday by The Lancet medical journal that were hailed by Moscow as an answer to its critics.

The results of the two trials, conducted in June-July this year and involving 76 participants, showed 100% of participants developing antibodies to the new coronavirus and no serious side effects, The Lancet said.

Russia licensed the two-shot jab for domestic use in August, the first country to do so and before any data had been published or a large-scale trial begun.

“The two 42-day trials – including 38 healthy adults each – did not find any serious adverse effects among participants, and confirmed that the vaccine candidates elicit an antibody response,” The Lancet said.

“Large, long-term trials including a placebo comparison, and further monitoring are needed to establish the long-term safety and effectiveness of the vaccine for preventing COVID-19 infection,” it said.

The vaccine is named Sputnik-V in homage to the world’s first satellite, launched by the Soviet Union. Some Western experts have warned against its use until all internationally approved testing and regulatory steps have been taken.

But with the results now published for the first time in an international peer-reviewed journal, and with a 40,000-strong later-stage trial launched last week, a senior Russian official said Moscow had faced down its critics abroad.

“With this (publication) we answer all of the questions of the West that were diligently asked over the past three weeks, frankly with the clear goal of tarnishing the Russian vaccine,” said Kirill Dmitriev, the head of the Russian Direct Investment Fund (RDIF), Russia’s sovereign wealth fund, which has backed the vaccine.

“All of the boxes are checked,” he told Reuters. “Now... we will start asking questions of some of the Western vaccines.”

Dmitriev said at least 3,000 people had already been recruited for the large-scale trial of the Sputnik-V vaccine launched last week, and initial results were expected in October or November this year.

Commenting on the results of the early-stage trials, lead author Dr Naor Bar-Zeev of the International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, USA said the studies were “encouraging but small”.

Bar-Zeev, who was not involved in the study, said “clinical efficacy for any COVID-19 vaccine has not yet been shown.”

RACE TO DEVELOP VACCINE

Governments and big pharmaceutical firms are racing to develop a vaccine to end the COVID-19 pandemic, which has killed more than 850,000 people globally and infected around 26 million.

More than half a dozen drugmakers are already conducting advanced clinical trials, each with tens of thousands of participants and several, including Britain’s AstraZeneca and U.S. drugmakers Moderna and Pfizer expect to know if their COVID-19 vaccines work and are safe by the end of this year.

The Lancet said the early-stage trials suggested the Sputnik-V vaccine produced a response in a component of the immune system known as T cells.

Scientists have been scrutinising the role played by T cells in battling coronavirus infection, with recent findings showing these cells may provide longer-term protection than antibodies.

The vaccine, developed by Moscow’s Gamaleya Institute, is administered in two doses, with each based on a different vector that normally causes the common cold: human adenoviruses Ad5 and Ad26.

Some experts have said that using this delivery mechanism could make a COVID-19 vaccine less effective, since many people have already been exposed to the Ad5 adenovirus and developed immunity to it.

In China and the United States, about 40% of people have high levels of antibodies from prior Ad5 exposure. In Africa, it could be has high as 80%, experts have said.

Denis Logunov, one of the vaccine’s developers at the Gamaleya Institute, told Reuters the vaccine uses a strong enough dose of Ad5 to overcome any earlier immunity, without compromising safety.

The booster dose, based on the rarer Ad26 adenovirus, provides further support because the likelihood of widespread immunity to both types in the population is minimal, he said.

Russia has said it expects to produce between 1.5 million and 2 million doses per month of its potential COVID-19 vaccine by the end of the year, gradually increasing production to 6 million doses a month.
But western countries prefer to ignore positive assessments like this, and are getting ready to impose on their people less efficient - and probably more expensive - vaccines. The least one should expect from governments is an open mind, but that's impossible when Russia is involved.
Now we just have to wait 9 months or so to see if it is safe:Image

“"I fancied myself as some kind of god....It is a sort of disease when you consider yourself some kind of god, the creator of everything, but I feel comfortable about it now since I began to live it out.” -- George Soros

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cassowary
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Re: Russia's Covid19 Vaccine According to The Lancet

Post by cassowary » Fri Sep 04, 2020 8:07 am

“Large, long-term trials including a placebo comparison, and further monitoring are needed to establish the long-term safety and effectiveness of the vaccine for preventing COVID-19 infection,” it said.
We still need to wait to see if it works and has no adverse side effects.
The Imp :D

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armchair_pundit
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Re: Russia's Covid19 Vaccine According to The Lancet

Post by armchair_pundit » Fri Sep 04, 2020 8:16 am

cassowary wrote:
Fri Sep 04, 2020 8:07 am
“Large, long-term trials including a placebo comparison, and further monitoring are needed to establish the long-term safety and effectiveness of the vaccine for preventing COVID-19 infection,” it said.
We still need to wait to see if it works and has no adverse side effects.
I'm sitting out ANY WuFlu vaccine for at least 1 year.

Not feeling the desire to be ANYBODY's test subject...

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Sertorio
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Joined: Fri Dec 16, 2016 3:12 am

Re: Russia's Covid19 Vaccine According to The Lancet

Post by Sertorio » Fri Sep 04, 2020 8:36 am

armchair_pundit wrote:
Fri Sep 04, 2020 8:16 am
cassowary wrote:
Fri Sep 04, 2020 8:07 am
“Large, long-term trials including a placebo comparison, and further monitoring are needed to establish the long-term safety and effectiveness of the vaccine for preventing COVID-19 infection,” it said.
We still need to wait to see if it works and has no adverse side effects.
I'm sitting out ANY WuFlu vaccine for at least 1 year.

Not feeling the desire to be ANYBODY's test subject...
I hope many Americans think likewise...

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armchair_pundit
Posts: 367
Joined: Thu Dec 15, 2016 7:23 pm

Re: Russia's Covid19 Vaccine According to The Lancet

Post by armchair_pundit » Fri Sep 04, 2020 11:07 am

Sertorio wrote:
Fri Sep 04, 2020 8:36 am
armchair_pundit wrote:
Fri Sep 04, 2020 8:16 am
cassowary wrote:
Fri Sep 04, 2020 8:07 am
“Large, long-term trials including a placebo comparison, and further monitoring are needed to establish the long-term safety and effectiveness of the vaccine for preventing COVID-19 infection,” it said.
We still need to wait to see if it works and has no adverse side effects.
I'm sitting out ANY WuFlu vaccine for at least 1 year.

Not feeling the desire to be ANYBODY's test subject...
I hope many Americans think likewise...
that's real petty, even for an America hater like you...

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Sertorio
Posts: 4005
Joined: Fri Dec 16, 2016 3:12 am

Re: Russia's Covid19 Vaccine According to The Lancet

Post by Sertorio » Fri Sep 04, 2020 11:24 am

armchair_pundit wrote:
Fri Sep 04, 2020 11:07 am
Sertorio wrote:
Fri Sep 04, 2020 8:36 am
armchair_pundit wrote:
Fri Sep 04, 2020 8:16 am

I'm sitting out ANY WuFlu vaccine for at least 1 year.

Not feeling the desire to be ANYBODY's test subject...
I hope many Americans think likewise...
that's real petty, even for an America hater like you...
Why petty? I am just reinforcing your feelings on this matter...

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cassowary
Posts: 4263
Joined: Thu Dec 15, 2016 11:30 pm

Re: Russia's Covid19 Vaccine According to The Lancet

Post by cassowary » Sat Sep 05, 2020 7:13 pm

armchair_pundit wrote:
Fri Sep 04, 2020 8:16 am
cassowary wrote:
Fri Sep 04, 2020 8:07 am
“Large, long-term trials including a placebo comparison, and further monitoring are needed to establish the long-term safety and effectiveness of the vaccine for preventing COVID-19 infection,” it said.
We still need to wait to see if it works and has no adverse side effects.
I'm sitting out ANY WuFlu vaccine for at least 1 year.

Not feeling the desire to be ANYBODY's test subject...
I think the older you are, the earlier you can take the vaccine due to higher risks of the CCP flu for old folks. If you are under 30, wait five years. If you are above 80, take the vaccine when it comes out. You got nothing to lose.
The Imp :D

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Sertorio
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Meanwhile, AstraZeneca vaccine...

Post by Sertorio » Wed Sep 09, 2020 1:01 am

AstraZeneca’s Covid-19 vaccine trial ON HOLD after adverse reaction of UK participant
8 Sep, 2020 22:27
https://www.rt.com/news/500207-astrazen ... cine-hold/

The Phase 3 trial of the Covid-19 vaccine developed by the University of Oxford and AstraZeneca has been paused, reportedly due to a suspected ‘serious adverse reaction’ by one of the participants in the UK.

AstraZeneca only said that its “standard review process triggered a pause to vaccination to allow review of safety data,” according to a statement by a company spokesperson on Tuesday. It was unclear whether the hold was self-imposed or ordered by a regulator, what the adverse reaction may have been, or when it might have happened.

Anonymous sources told the news site Stat that the participant is “expected to recover,” but the information could not be independently confirmed.

AstraZeneca’s vaccine is the first Covid-19 trial put on hold upon reaching Phase 3, according to Stat. The study on phases one and two, published in July by the medical journal Lancet, noted that about 60 percent of the participants had developed side effects – fever, headaches, muscle pain, and injection site reactions, mainly – that were described as “mild or moderate” and subsided during the course of the trials.

It is unclear what effect the UK pause will have on the plans for Phase 3 testing in the US, which is supposed to enroll some 30,000 participants at 80 locations, according to the National Institutes of Health.

AstraZeneca’s vaccine client, AZD1222, uses an adenovirus that shares a gene with SARS-Cov-2, the coronavirus that causes Covid-19. The adenovirus platform is considered experimental in the West, but has served as the basis for Russia’s own vaccine for the coronavirus, dubbed Sputnik-V, which was rolled out to the public this week.

A peer-reviewed study of the early stages of Sputnik-V testing, published by The Lancet last week, suggested the Russian vaccine was both effective and safe. The journal noted that longer-term trials, including a placebo comparison, would be required to establish its bona fides beyond a reasonable doubt.
I wonder what those countries which rushed to order the AstraZeneca vaccine will now do. Order the apparently efficient and harmless Russian vaccine?... No! Western countries cannot be seen supporting anything Russian. Besides, you never know how much Novichok has slipped into the Russian vaccine...

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Doc
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Re: Meanwhile, AstraZeneca vaccine...

Post by Doc » Wed Sep 09, 2020 10:42 am

Sertorio wrote:
Wed Sep 09, 2020 1:01 am
AstraZeneca’s Covid-19 vaccine trial ON HOLD after adverse reaction of UK participant
8 Sep, 2020 22:27
https://www.rt.com/news/500207-astrazen ... cine-hold/

The Phase 3 trial of the Covid-19 vaccine developed by the University of Oxford and AstraZeneca has been paused, reportedly due to a suspected ‘serious adverse reaction’ by one of the participants in the UK.

AstraZeneca only said that its “standard review process triggered a pause to vaccination to allow review of safety data,” according to a statement by a company spokesperson on Tuesday. It was unclear whether the hold was self-imposed or ordered by a regulator, what the adverse reaction may have been, or when it might have happened.

Anonymous sources told the news site Stat that the participant is “expected to recover,” but the information could not be independently confirmed.

AstraZeneca’s vaccine is the first Covid-19 trial put on hold upon reaching Phase 3, according to Stat. The study on phases one and two, published in July by the medical journal Lancet, noted that about 60 percent of the participants had developed side effects – fever, headaches, muscle pain, and injection site reactions, mainly – that were described as “mild or moderate” and subsided during the course of the trials.

It is unclear what effect the UK pause will have on the plans for Phase 3 testing in the US, which is supposed to enroll some 30,000 participants at 80 locations, according to the National Institutes of Health.

AstraZeneca’s vaccine client, AZD1222, uses an adenovirus that shares a gene with SARS-Cov-2, the coronavirus that causes Covid-19. The adenovirus platform is considered experimental in the West, but has served as the basis for Russia’s own vaccine for the coronavirus, dubbed Sputnik-V, which was rolled out to the public this week.

A peer-reviewed study of the early stages of Sputnik-V testing, published by The Lancet last week, suggested the Russian vaccine was both effective and safe. The journal noted that longer-term trials, including a placebo comparison, would be required to establish its bona fides beyond a reasonable doubt.
I wonder what those countries which rushed to order the AstraZeneca vaccine will now do. Order the apparently efficient and harmless Russian vaccine?... No! Western countries cannot be seen supporting anything Russian. Besides, you never know how much Novichok has slipped into the Russian vaccine...
The Very Rushed Russian vaccine has not been tested to world standards. The history is clear as to what can happen when drugs are not tested to those standards



This is not to say the Russian vaccine is safe to use or effective to prevent the CCP virus. But this vaccine whatever form it may come in, will be the most complex vaccine ever formulated. Some reactions to the CCP virus has indicated that vaccines(any of them) may make the CCP virus much more deadly. In the end there is a good chance there will NEVER BE a vaccine for the CCP virus. We have been promised a vaccine for SARS since 2003. That has never happened. There is no vaccine for the common cold. One third of all colds are caused by coronavirus. Also we have been promised a vaccine for HIV since 1990 none has ever come to be.
“"I fancied myself as some kind of god....It is a sort of disease when you consider yourself some kind of god, the creator of everything, but I feel comfortable about it now since I began to live it out.” -- George Soros

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